In futuro basterà una sola pillola per eradicare l’infezione

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«Le opzioni terapeutiche di cui disponiamo, incluse le più recenti, nonostante la loro indiscutibile efficacia, lasciano aperti numerosi problemi: sono attive principalmente contro i genotipi 1 e 4 di HCV, e molto meno efficaci per circa un terzo dei pazienti, quelli con genotipo 2 e 3, e non danno risposte soddisfacenti in presenza di cirrosi compensata e scompensata.

Merck’s grazoprevir/elbasvir combo shows high cure rates, including for people with cirrhosis and HIV/HCV co-infection

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An all-oral regimen of
grazoprevir (MK-5172) and elbasvir (MK-8742), taken with or without
ribavirin for 12 weeks, demonstrated high sustained virological response (SVR) rates
for treatment-naive and treatment-experienced people with genotype 1 hepatitis
C virus (HCV), including people with liver cirrhosis and HIV and HCV co-infection,
researchers reported on Tuesday at
the American Association for the

Sofosbuvir/ledipasvir and AbbVie 3D regimen cure most people with HCV genotype 4

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Sofosbuvir/ledipasvir without
ribavirin and AbbVie’s 3D regimen (paritaprevir/ombitasvir plus dasabuvir) both
produced high sustained virological response rates for people with hepatitis C
virus (HCV) genotype 4, according to a pair of studies presented at the American Association for the Study of Liver
Diseases (AASLD) Liver Meeting this week in Boston, USA.
HCV genotype 4, the
most

Restoring and maintaining a high CD4 count possible for vast majority of people living with HIV in France

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A large French study has shown that the vast
majority of people living with HIV who started treatment since 2000 in a
national cohort achieved a CD4 cell count in the normal range within three to
four years of starting treatment, while a large Italian study showed that
achieving a normal CD4 count on

Sofosbuvir/ledipasvir with ribavirin is highly effective for people with decompensated cirrhosis

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An oral regimen of
sofosbuvir/ledipasvir plus ribavirin taken for 12 weeks cured most hepatitis C
patients with decompensated cirrhosis, the most advanced stage of liver
disease, according to a presentation on Tuesday at the American Association for the Study of Liver
Diseases (AASLD) Liver Meeting in Boston.
Over years or decades,
chronic hepatitis C virus (HCV)

People living with HIV have high survival rates after liver transplants due to HCC

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People with HIV – most of whom had hepatitis B
or C co-infection – generally had good outcomes after liver transplantation due
to hepatocellular carcinoma (HCC), with five-year survival rates similar to
those of HIV-negative transplant recipients and better than those of people who
underwent other types of liver cancer treatment, researchers reported this

What are the barriers that could stop HIV treatment becoming HIV prevention?

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One of the key strategies involved in trying to bring an end
to the HIV epidemic is to increase the proportion of HIV-positive people on antiretroviral
therapy (ART), to the point where suppressing their viral load starts to reduce
onward infection.
What is usually called ‘treatment as prevention’ lies behind
the
ambitious new target announced

Young drug injectors on opioid maintenance therapy have lower risk of hepatitis C infection

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Young people who inject drugs (PWID) who undergo opioid
agonist maintenance therapy with methadone or buprenorphine have more than a
60% reduced risk of acquiring hepatitis C virus (HCV) over time
compared to those with no substance use treatment, according to a study presented Monday at the American Association for the Study
of Liver

Misunderstanding of questions regarding anal sex in microbicide HIV prevention trial

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There was widespread misunderstanding and misinterpretation of questions
about anal sex being asked of participants inthe Vaginal
and Oral Interventions to Control the Epidemic (VOICE) trial existed, according to findings of a qualitative
ancillary study to the VOICE trial qualitative
analysis study (called MTN-003D or VOICE-D) presented at the HIV Research for Prevention conference

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